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Resistors are basic yet essential circuit components that must be fabricated with high precision at low cost if they are to be viable for flexible electronic applications. Inkjet printing is one of many additive fabrication techniques utilized to realize this goal. In this work, a process termed self-aligned capillarity-assisted lithography for electronics (SCALE) was used to fabricate inkjet-printed resistors on flexible substrates. Capillary channels and reservoirs imprinted onto flexible substrates enabled precise control of resistor geometry and straightforward alignment of materials. More than 300 devices were fabricated using poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) as the resistive material and silver as the electrode material. By varying PEDOT:PSS ink formulation and resistor geometry, resistances spanning from 170 Ω to 3.8 MΩ were achieved. Over 98% of devices were functional and the relative standard deviation in resistance ranged from 3% to 18% depending on resistor length and ink composition. The resistors showed no significant change in resistance after 10 000 cycles of bend testing at 1.6% surface tensile strain. In summary, this work demonstrated a fully roll-to-roll compatible process for inkjet printing resistors with superior properties.

 

With the aim of analyzing large-sized multidimensional single-cell datasets, we are describing a method for Cosine-based Tanimoto similarity-refined graph for community detection using Leiden’s algorithm (CosTaL). As a graph-based clustering method, CosTaL transforms the cells with high-dimensional features into a weighted k-nearest-neighbor (kNN) graph. The cells are represented by the vertices of the graph, while an edge between two vertices in the graph represents the close relatedness between the two cells. Specifically, CosTaL builds an exact kNN graph using cosine similarity and uses the Tanimoto coefficient as the refining strategy to re-weight the edges in order to improve the effectiveness of clustering. We demonstrate that CosTaL generally achieves equivalent or higher effectiveness scores on seven benchmark cytometry datasets and six single-cell RNA-sequencing datasets using six different evaluation metrics, compared with other state-of-the-art graph-based clustering methods, including PhenoGraph, Scanpy and PARC. As indicated by the combined evaluation metrics, Costal has high efficiency with small datasets and acceptable scalability for large datasets, which is beneficial for large-scale analysis.

 

The Consultative Committee for Space Data Systems (CCSDS) 141.11-O-1 Line Product Code (LPC) provides a rare opportunity to compare maximum-likelihood decoding and message passing. The LPC considered in this paper is intended to serve as the inner code in conjunction with a (255,239) Reed Solomon (RS) code whose symbols are bytes of data. This paper represents the 141.11-O-1 LPC as a bipartite graph and uses that graph to formulate both maximum likelihood (ML) and message passing algorithms. ML decoding must, of course, have the best frame error rate (FER) performance. However, a fixed point implementation of a Neural-Normalized MinSum (N-NMS) message passing decoder closely approaches ML performance with a significantly lower complexity. 

Single particle analysis cryo-electron microscopy (EM) and molecular dynamics (MD) have been complimentary methods since cryo-EM was first applied to the field of structural biology. The relationship started by biasing structural models to fit low-resolution cryo-EM maps of large macromolecular complexes not amenable to crystallization. The connection between cryo-EM and MD evolved as cryo-EM maps improved in resolution, allowing advanced sampling algorithms to simultaneously refine backbone and sidechains. Moving beyond a single static snapshot, modern inferencing approaches integrate cryo-EM and MD to generate structural ensembles from cryo-EM map data or directly from the particle images themselves. We summarize the recent history of MD innovations in the area of cryo-EM modeling. The merits for the myriad of MD based cryo-EM modeling methods are discussed, as well as, the discoveries that were made possible by the integration of molecular modeling with cryo-EM. Lastly, current challenges and potential opportunities are reviewed. 

Neural Normalized MinSum (N-NMS) decoding delivers better frame error rate (FER) performance on linear block codes than conventional Normalized MinSum (NMS) by assigning dynamic multiplicative weights to each check-to-variable node message in each iteration. Previous N-NMS efforts primarily investigated short block codes (N < 1000), because the number of N-NMS parameters required to be trained scales proportionately to the number of edges in the parity check matrix and the number of iterations. This imposes an impractical memory requirement for conventional tools such as Pytorch and Tensorflow to create the neural network and store gradients. This paper provides efficient methods of training the parameters of N-NMS decoders that support longer block lengths. Specifically, this paper introduces a family of Neural 2-dimensional Normalized (N-2D-NMS) decoders with various reduced parameter sets and shows how performance varies with the parameter set selected. The N-2D-NMS decoders share weights with respect to check node and/or variable node degree. Simulation results justify a reduced parameter set, showing that the trained weights of N- NMS have a smaller value for the neurons corresponding to larger check/variable node degree. Further simulation results on a (3096,1032) Protograph-Based Raptor-Like (PBRL) code show that the N-2D-NMS decoder can achieve the same FER as N- NMS while also providing at least a 99.7% parameter reduction. Furthermore, the N-2D-NMS decoder for the (16200,7200) DVBS- 2 standard LDPC code shows a lower error floor than belief propagation. Finally, this paper proposes a hybrid decoder training structure that utilizes a neural network which combines a feedforward module with a recurrent module. The decoding performance and parameter reduction of the hybrid training depends on the length of recurrent module of the neural network. 

Serial femtosecond crystallography (SFX) is a powerful technique that exploits X-ray free-electron lasers to determine the structure of macromolecules at room temperature. Despite the impressive exposition of structural details with this novel crystallographic approach, the methods currently available to introduce crystals into the path of the X-ray beam sometimes exhibit serious drawbacks. Samples requiring liquid injection of crystal slurries consume large quantities of crystals (at times up to a gram of protein per data set), may not be compatible with vacuum configurations on beamlines or provide a high background due to additional sheathing liquids present during the injection. Proposed and characterized here is the use of an immiscible inert oil phase to supplement the flow of sample in a hybrid microfluidic 3D-printed co-flow device. Co-flow generation is reported with sample and oil phases flowing in parallel, resulting in stable injection conditions for two different resin materials experimentally. A numerical model is presented that adequately predicts these flow-rate conditions. The co-flow generating devices reduce crystal clogging effects, have the potential to conserve protein crystal samples up to 95% and will allow degradation-free light-induced time-resolved SFX.